Leibovich et al. challenge the prevailing view that non-symbolic number sense is innate, that detection of numerosity is distinct from detection of continuous magnitude. In the present commentary, the authors' viewpoint is discussed in light of the integrative theory of numerical development along with implications for understanding mathematics disabilities.

(2004). What is the Role of the Precautionary Principle in the Philosophy of Medicine and Bioethics? Journal of Medicine and Philosophy: Vol. 29, No. 3, pp. 255-258.

Being able to estimate quantity is important in everyday life and for success in the STEM disciplines. However, people have difficulty reasoning about magnitudes outside of human perception. This study examines patterns of estimation errors across temporal and spatial magnitudes at large scales. We evaluated the effectiveness of hierarchical alignment in improving estimations, and transfer across dimensions. The activity was successful in increasing accuracy for temporal and spatial magnitudes, and learning transferred to the estimation of numeric magnitudes associated with events (...) and objects. However, there were also a number of informative differences in performance on temporal, spatial, and numeric magnitude measures, suggesting that participants possess different categorical information for these scales. Educational implications are discussed. (shrink)

Memory for spatial location is typically biased, with errors trending toward the center of a surrounding region. According to the category adjustment model, this bias reflects the optimal, Bayesian combination of fine-grained and categorical representations of a location. However, there is disagreement about whether categories are malleable. For instance, can categories be redefined based on expert-level conceptual knowledge? Furthermore, if expert knowledge is used, does it dominate other information sources, or is it used adaptively so as to minimize overall error, (...) as predicted by a Bayesian framework? We address these questions using images of geological interest. The participants were experts in structural geology, organic chemistry, or English literature. Our data indicate that expertise-based categories influence estimates of location memory—particularly when these categories better constrain errors than alternative categories. Results are discussed with respect to the CAM. (shrink)

The Code of Ethics of the American Speech-Language-Hearing Associations states....hold paramount the welfare of persons served professionally. But how do clinicians balance the financial demands of their service-oriented business with their interest in the welfare of the people they serve? In this text, Dr Resnick explores the various aspects of applied ethics to give speech-pathologists and audiologists a better understanding of professional ethics and what it means for the conduct of a profession. Solving ethical dilemmas, working with ethics committees, (...) and other practical issues are covered to promote the preservation of professional ethics in daily practice. (shrink)

: Some industry relationships are a good idea, and that makes banning the dangerous ones difficult.

This paper examines Albert the Great’s conception of the body’s humoral complexion to consider not only the manner in which it presents in individuals, but also the manner in which it defines entire peoples or communities to produce a rudimentary ethnoanthropology in support of theological goals. In particular, I shall examine efforts to identify a sanguineous human complexion as best, leading to a logical inference that both Jesus and the Virgin Mary possessed this complexion. Then, I shall explore efforts to (...) identify diaspora Jews in general as possessors of an inferior, melancholy complexion, which effectively dejudaizes Jesus and Mary. Last, I shall examine attempts to depict the Jews’ complexion as uniquely incapable of alteration, perpetuating a distempered complexion that distances them from both the supralapsarian Adamic body and from the corporeal balance and harmony of the ideal Christian body. (shrink)

With more than 700 specific strategies and solutions to use in the classroom, school, and community, this book covers just about everything that educators need, providing a comprehensive and detailed blueprint for an overall plan and policy to prevent and deal with peer harassment.

The earlier volume in this series dealt with two religions of Indian origin, namely, Buddhism and Jainism. The Indian religious scene, however, is characterized by not only religions which originated in India but also by religions which entered India from outside India and made their home here. Thus religious life in India has been enlivened throughout its history by the presence of religions of foreign origin on its soil almost from the very time they came into existence. This volume covers (...) three such religions—Zoraoastrianism, Judaism, and Islam. In the case of Zoraostianism, even its very beginnings are intertwined with India, as Zoroastrianism reformed a preexisting religion which had strong links to the Vedic heritage of India. This relationship took on a new dimension when a Zoroastrian community, fearing persecution in Persia after its Arab conquest, sought shelter in western India and ultimately went on to produce India’s pioneering nationalist in the figure of Dadabhai Naoroji ( 1825-1917), also known as the Grand Old Man of India. Jews found refuge in south India after the destruction of the Temple by the Romans in 70 C.E. and have remained a part of the Indian religious scene since then, some even returning to Israel after it was founded in 1948. Islam arrived in Kerala as soon as it was founded and one of the earliest mosques in the history of Islam is found in India. Islam differs from the previously mentioned religions inasmuch as it went on to gain political hegemony over parts of the country for considerable periods of time, which meant that its impact on the religious life of the subcontinent has been greater compared to the other religions. It has also meant that Islam has existed in a religiously plural environment in India for a longer period than elsewhere in the world so that not only has Islam left a mark on India, India has also left its mark on it. Indeed all the three religions covered in this volume share this dual feature, that they have profoundly influenced Indian religious life and have also in turn been profoundly influenced by their presence in India. (shrink)

The earlier volume in this series dealt with two religions of Indian origin, namely, Buddhism and Jainism. The Indian religious scene, however, is characterized by not only religions which originated in India but also by religions which entered India from outside India and made their home here. Thus religious life in India has been enlivened throughout its history by the presence of religions of foreign origin on its soil almost from the very time they came into existence. This volume covers (...) three such religions—Zoraoastrianism, Judaism, and Islam. In the case of Zoraostianism, even its very beginnings are intertwined with India, as Zoroastrianism reformed a preexisting religion which had strong links to the Vedic heritage of India. This relationship took on a new dimension when a Zoroastrian community, fearing persecution in Persia after its Arab conquest, sought shelter in western India and ultimately went on to produce India’s pioneering nationalist in the figure of Dadabhai Naoroji ( 1825-1917), also known as the Grand Old Man of India. Jews found refuge in south India after the destruction of the Temple by the Romans in 70 C.E. and have remained a part of the Indian religious scene since then, some even returning to Israel after it was founded in 1948. Islam arrived in Kerala as soon as it was founded and one of the earliest mosques in the history of Islam is found in India. Islam differs from the previously mentioned religions inasmuch as it went on to gain political hegemony over parts of the country for considerable periods of time, which meant that its impact on the religious life of the subcontinent has been greater compared to the other religions. It has also meant that Islam has existed in a religiously plural environment in India for a longer period than elsewhere in the world so that not only has Islam left a mark on India, India has also left its mark on it. Indeed all the three religions covered in this volume share this dual feature, that they have profoundly influenced Indian religious life and have also in turn been profoundly influenced by their presence in India. (shrink)

© Copyright 2015, Mary Ann Liebert, Inc..Signal transducer and activator of transcription factor 3 is hyperactivated in head and neck squamous cell carcinomas. Cumulative evidence indicates that IL-6 production by HNSCC cells and/or stromal cells in the tumor microenvironment activates STAT3 and contributes to tumor progression and drug resistance. A library of 94,491 compounds from the Molecular Library Screening Center Network was screened for the ability to inhibit interleukin-6 -induced pSTAT3 activation. For contractual reasons, the primary high-content screening campaign was (...) conducted over several months in 3 distinct phases; 1,068 primary HCS actives remained after cytotoxic or fluorescent outliers were eliminated. One thousand one hundred eighty-seven compounds were cherry-picked for confirmation; actives identified in the primary HCS and compounds selected by a structural similarity search of the remaining MLSCN library using hits identified in phases I and II of the screen. Actives were confirmed in pSTAT3 IC50 assays, and an IFNγ-induced pSTAT1 activation assay was used to prioritize selective inhibitors of STAT3 activation that would not inhibit STAT1 tumor suppressor functions. Two hundred three concentration-dependent inhibitors of IL-6-induced pSTAT3 activation were identified and 89 of these also produced IC50s against IFN-γ-induced pSTAT1 activation. Forty-nine compounds met our hit criteria: they reproducibly inhibited IL-6-induced pSTAT3 activation by ≥70% at 20 μM; their pSTAT3 activation IC50s were ≤25 μM; they were ≥2-fold selective for pSTAT3 inhibition over pSTAT1 inhibition; a cross target query of PubChem indicated that they were not biologically promiscuous; and they were ≥90% pure. Twenty-six chemically tractable hits that passed filters for nuisance compounds and had acceptable drug-like and ADME-Tox properties by computational evaluation were purchased for characterization. The hit structures were distributed among 5 clusters and 8 singletons. Twenty-four compounds inhibited IL-6-induced pSTAT3 activation with IC50s ≤20 μM and 13 were ≥3-fold selective versus inhibition of pSTAT1 activation. Eighteen hits inhibited the growth of HNSCC cell lines with average IC50s ≤ 20 μM. Four chemical series were progressed into lead optimization: the guanidinoquinazolines, the triazolothiadiazines, the amino alcohols, and an oxazole-piperazine singleton. (shrink)

Odo of Tournai, the Phoenix, and the Problem of Universals IRVEN M. RESNICK OVER THE PAST SEVERAL YEARS a good deal of attention has been focused on the philosophical literature of the late eleventh and early twelfth centuries in an attempt to locate the origins of nominalism? As part of this effort, several scholars have attempted to come to a new and better appreciation of one of the most vilified figures of the late eleventh century, namely Roscelin of Com- (...) pi~gne, whose logical doctrine, sometimes described as "proto-nominalism" or "vocalism, ''2 represents an early stage in the development of twelfth-century logical thought. Some have attempted simply to reconstruct, on the basis of the little material available to us that describes Roscelin's views, a less polemical and more coherent account of his theory of universals.3 Others have attempted to identify additional writings -- both published and unpublished -- that may prop- erly shed light on Roscelin's philosophy.4 All, however, would agree on Roscelin's significance for the history of philosophy at the beginning of the twelfth-century renaissance. Roscelin's importance does not necessarily presuppose his originality. Evi- ' This effort has resulted in the dedication of an entire number of Vivarium to the origin and meaning of twelfth-century nominalism. Cf. Vivarium 3o/1 . For a discussion of various doctrines on universals that emerged before Abelard, see Augustine Thompson, "The Debate.. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Before Science: The Invention of the Friars’ Natural Philosophy by Roger French, Andrew CunninghamIrven M. ResnickRoger French and Andrew Cunningham. Before Science: The Invention of the Friars’ Natural Philosophy. Hants, UK: Scolar Press, 1996. Pp. x + 298. Cloth, $68.95.This is a peculiar book that depicts thirteenth-century natural philosophy as wholly dependent on the theological interests of the mendicant orders. For the Friars, “Natural philosophy was a study (...) in which the central concerns were the detection, admiration and appreciation of God’s existence, goodness, providence, munificence, forethought and provision for His creation” (4). Although conceived as “a positive contribution to the discipline of the history of science” (3), the work begins and ends with the claim that medieval natural philosophers were not engaged in science.One difficulty is that the authors never make clear what they mean by science, although they evidently understand that it entails a repudiation of metaphysics and a doctrine of nature’s radical autonomy. Consequently, for French and Cunningham medieval “science” is a mythic construct of modern historians, since “[t]here was no scientific tradition (in the modern sense of the term ‘scientific’) of looking at nature in the thirteenth century, only a religio-political way of doing so” (273).Thus, when summarizing the accomplishments of Roger Bacon, they note that “[Bacon] has been credited, along with Grosseteste, with creating early ‘experimental science’. Bacon could not of course have been a ‘scientist’ because he lived in the wrong [End Page 623] age for this” (238). This seemingly casual conclusion is rather stunning not only in its own right, but also as a revelation of the authors’ own effort to disenfranchise medieval ‘scientists’ for having had the misfortune of living too soon.French and Cunningham propose that polemical or apologetical interests urged the Friars to study nature as a response to various heretics and especially the Cathars who, seemingly like moderns, sought to disengage the natural world from the Christian God, while using the vocabulary of Aristotle’s libri naturales. However this central argument demands better support. Since the authors can cite only one surviving Cathar text—De duobus principiis (ca. 1230)—almost everything known of this group is derived from anti-Cathar polemics. Based on this single text the authors can say no more than that it used “what looks very much like a commentary on Aristotle’s Physics or Metaphysics,” (134) but fail to identify more precisely its sources. It is clear that thirteenth-century orthodox polemics increasingly relied on Aristotelian materials, but the conclusion that natural philosophers did so only in response to heretics who beat them to the Aristotelian punch seems tendentious. The historian will likely remain unconvinced that the unparalleled translating activity of the late eleventh and twelfth centuries—the rendering into Latin of Arabic scientific knowledge (as in Constantine the African’s Pantegni or Adelard of Bath’s Quaestiones naturales), Greek medical literature (e.g. Galen’s Methodus medendi translated by Gerard of Cremona and Burgundio of Pisa) and mathematics (e.g. Euclid’s Optics, Theodosius’s Spherics, Archimedes’ On the Quadrature of the Circle, and Ptolemy’s Tetrabiblos and Almagest) culminating with thirteenth-century translations of Aristotle’s biological works—should all have stemmed from a preoccupation with heresy.A further shortcoming of this book is the limited attention given to works on natural philosophy by the Friars themselves. The book’s first seven of eleven chapters explore the educational establishments in which natural philosophy arose: first monastic and cathedral schools, and then the universities. The works of individual Friars receive only the briefest summary. Among the Dominican natural philosophers Albertus Magnus—the patron saint of scientists and one of a very few scholastics to have commented on all of Aristotle’s biological works—is awarded only five pages. For his mastery of Aristotle’s libri naturales Albertus has been called “the dominant figure in Latin learning and natural science of the thirteenth century.” (Cf. Lynn Thorndike, History of Magic and Experimental Science [New York: Macmillan, 1929], 2:521) Albertus described not only the natural world but also explored the philosophical foundations for scientific knowledge. Yet curiously French and Cunningham give much more attention... (shrink)

It is quite difficult to respond briefly and effectively to such a devastating charge as that the only merit your book has is that it is honest. My strategy will be, by showing that a few of Resnick's criticisms are ill-taken, to generate the presumption that the same could be said of a lot more of them. I will first discuss some minor points, and then two larger issues.

Contributions to this omnibus volume from twenty-seven internationally renowned scholars will introduce students of philosophy, science, and theology to the current state of research and multiple perspectives on the work of Albert the Great.

This article discusses some ethical issues that can arise when researchers decide to increase the amount of payment offered to research subjects to boost enrollment. Would increasing the amount of payment be unfair to subjects who have already consented to participate in the study? This article considers how five different models of payment—the free market model, the wage payment model, the reimbursement model, the appreciation model, and the fair benefits model—would approach this issue. The article also considers several practical problems (...) related to changing the amount of payment, including determining whether there is enough money in the budget to offer additional payments to subjects who have already enrolled, ascertaining how difficult it will be to re-contact subjects, and developing a plan of action for responding to subjects who find out they are receiving less money and demand an explanation. (shrink)

This study described the relationships between academic class and student moral sensitivity and reasoning and between curriculum design components for ethics education and student moral sensitivity and reasoning. The data were collected from freshman (n = 506) and senior students (n = 440) in eight baccalaureate nursing programs in South Korea by survey; the survey consisted of the Korean Moral Sensitivity Questionnaire and the Korean Defining Issues Test. The results showed that moral sensitivity scores in patient-oriented care and conflict were (...) higher in senior students than in freshman students. Furthermore, more hours of ethics content were associated with higher principled thinking scores of senior students. Nursing education in South Korea may have an impact on developing student moral sensitivity. Planned ethics content in nursing curricula is necessary to improve moral sensitivity and moral reasoning of students. (shrink)

Irven Michael Resnick - Jews and Christians in Twelfth-Century Europe - Journal of the History of Philosophy 40:2 Journal of the History of Philosophy 40.2 257-258 Book Review Jews and Christians in Twelfth-Century Europe Michael A. Signer and John Van Engen, editors. Jews and Christians in Twelfth-Century Europe. Notre Dame: University of Notre Dame Press, 2001. Pp. xi + 380. Cloth, $49.95. Paper, $24.95. This volume, a collection of conference papers presented at Notre Dame in 1996, draws attention to (...) the twelfth-century renaissance for the evolution of medieval Jewish-Christian relations. Rather than treating the anti-Jewish violence of the first Crusade as a decisive break leading directly to Jewish isolation and, finally, expulsion from medieval Christendom, the editors have selected papers that seek "to integrate the Jewish and Jewish-Christian stories into a larger European story" focusing.. (shrink)

The existence and unity of a discipline called economics reside in the eye and mind of the beholder. The perception of economics's unity and disciplinarity itself arises in some, but not all, of the different schools of thought that we would loosely categorize as economic. Indeed, as we hope to show, the presumption of unity and disciplinarity—the idea that there is a center or “core” of propositions, procedures, and conclusions or a shared historical “object” of theory and practice—is suggested in (...) the concepts and methods of some schools of economic thought, but is opposed by others. Further, we argue that the portrayal of economics as a discipline with distinct boundaries is often a discursive strategy by one school or another to hegemonize the field of economic discourse. In this way, the issue of the existence of an economics discipline and its principles of unity or dispersion is in part a political question. Its effects are felt in the hiring and firing of economics professors and practitioners, the determination of what comprises an economics curriculum, the determination of what is a legitimate economic argument and what is not, the dispensation of public and private grant monies, and the differential entry into or exclusion from ideological, political, and economic centers of power and decision making.Our view is that no discipline of economics exists. Or, rather, no unified discipline exists. The “discipline” of economics is actually an agonistic and shifting field of fundamentally different and often conflicting discourses. The dispersion and divisions that exist between the schools of thought we discuss here as “economic” may have some regularities. But we do not see closer contiguity of these economic schools when placed on a horizontal scale than, to take just one example, among all of the many different "disciplinary" forms of Marxian thought. That is, in our view, Marxian economic thought shares more concepts, approaches, and methods—may have more discursive regularity—with Marxian literary theory than do Marxian economic thought and neoclassical economic theory. Jack Amariglio is associate professor of economics at Merrimack College and the editor of Rethinking Marxism: A Journal of Economics, Culture, and Society. He is working on a book entitled Modernism and Postmodernism in Economics with Arjo Klamer. Stephen Resnick and Richard Wolff are professors of economics at the University of Massachusetts, Amherst. Their recent coauthored books are Knowledge and Class: A Marxian Critique of Political Economy and Economics: Marxian versus Neoclassical. (shrink)

This paper is an update of the documents we have concerning the Acts of the Christian martyrs, focused on three main aspects: 1) the kind of acts we know of and their classification from the point of view of their historic value; 2) the versions or editions of the texts that are most accepted by scholars; 3) the relevance of the different parts that make up these documents in order to discern the original text from passages that were rewritten or (...) underwent later variations. In this way, the article offers an exhaustive list of the documents for use in researching Christian martyrs in the Roman period. (shrink)

In recent literature, panpsychism has been defended by appeal to two main arguments: first, an argument from philosophy of mind, according to which panpsychism is the only view which successfully integrates consciousness into the physical world (Strawson 2006; Chalmers 2013); second, an argument from categorical properties, according to which panpsychism offers the only positive account of the categorical or intrinsic nature of physical reality (Seager 2006; Adams 2007; Alter and Nagasawa 2012). Historically, however, panpsychism has also been defended by appeal (...) to a third argument based on considerations about the nature and observability of causation. This argument has not been much discussed in recent times. Here is a concise version from William James: "… the concrete perceptual flux, taken just as it comes, offers in our own activity-situations perfectly comprehensible instances of causal agency … If we took these experiences as the type of what actual causation is, we should have to ascribe to cases of causation outside of our life, to physical cases also, an inwardly experiential nature. In other words, we should have to espouse a so-called “pan-psychic” philosophy" (James 1911: 218). James here suggests that we have direct experience of causation in our own agency. He thereby directly contradicts David Hume, who famously denied that we have any experience of causation. James goes on to claim that if this experience is representative of causation in general, it follows that all causation is mental, and that panpsychism is true. This kind of argument for panpsychism can be called the argument from (experience of) causation. This chapter offers, first, a history of this argument and arguments closely related to it, and second, an analysis of the argument – is it valid, are its premises in any way defensible, and how does it relate to the other, more popular arguments for panpsychism from philosophy of mind and categorical properties? (shrink)

This book gives an excellent introduction to the theory of special relativity. Professor Resnick presents a fundamental and unified development of the subject with unusually clear discussions of the aspects that usually trouble beginners. He includes, for example, a section on the common sense of relativity. His presentation is lively and interspersed with historical, philosophical and special topics (such as the twin paradox) that will arouse and hold the reader's interest. You'll find many unique features that help you grasp (...) the material, such as worked-out examples,summary tables,thought questions and a wealth of excellent problems. The emphasis throughout the book is physical. The experimental background, experimental confirmation of predictions, and the physical interpretation of principles are stressed. The book treats relativistic kinematics, relativistic dynamics, and relativity and electromagnetism and contains special appendices on the geometric representation of space-time and on general relativity. Its organization permits an instructor to vary the length and depth of his treatment and to use the book either with or following classical physics. These features make it an ideal companion for introductory courses. (shrink)

Ibn al-ʻArabī, 1165-1240; views on freedom; Sufism; Islamic philosophy.

This essay provides a rationale for a regulated market for human oocytes. Although the commodification of human oocytes raises important moral concerns, these concerns do not justify laws banning commerce in human eggs. Given the burgeoning ART industry and the growing oocyte market, the most prudent course of action is to develop regulations for the human oocyte market that are designed to protect and promote important social values, such as health, safety, liberty, and respect for human life. Other responses, such (...) as banning the sale of eggs altogether or allowing donors to be compensated only for their services, would either create a black market or would lead to corruption and abuse. Society still needs to debate specific rules and policies that should govern the human egg market, but further discussion of that important task is best left to legislative bodies and other commentators. (shrink)

With the advancement of medical technology, various life-sustaining treatments are available at the end of life. Older adults should be encouraged to establish their end-of-life treatment preferences (ELTP) while they are physically and mentally able to do so. The purpose of this study was to explore ELTP among older adults and to compare those preferences in a subset of individuals who had reported their ELTP in a survey completed the previous year. This was a descriptive study of 191 older adults (...) living in a continuing care retirement community. Approximately half of the participants did not want cardiopulmonary resuscitation, to be put on a respirator, or to receive dialysis. The findings in this study suggest that many older adults do not want aggressive interventions at the end of life, but choose rather those measures that will keep them comfortable. Moreover, treatment choices may change over time. Health care providers should initiate discussions about ELTP at regular intervals (yearly) to assist older adults in dictating their end-of-life care. (shrink)

The very purpose of traditional—especially religious—education is to induct the young into a unique vision of reality. When the compelling religious vision conflicts with other visions, extremist confrontations may result. This paper explores ways to 'square the circle' of the educational conundrum of how to educate for fervent commitment to tradition without precluding autonomy and diversity, both within the tradition but especially vis-à-vis outsiders. Some liberal educators see educating for autonomy as an antidote to extremism, but such an approach is (...) found wanting both ethically and empirically. Reinforcing the roots of toleration within religious traditions is offered as a more effective alternative. (shrink)